Description
Recombinant human TNK1 (1-510) was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag. The gene accession number is NM_003985.
TNK1 or tyrosine kinase, non-receptor 1 belongs to the tyrosine protein kinase family which are important regulators of intracellular signal transduction pathways mediating cellular proliferation, survival, and development. TNK1 is highly expressed in fetal tissues and at lower levels in few adult tissues. TNK1 may function in signaling pathways utilized broadly during fetal development, and more selectively in adult tissues. TNK1 plays a negative regulatory role in the Ras-Raf1-MAPK pathway, and knockout mice have been shown to develop spontaneous tumors, suggesting a role as a tumor suppressor gene (1)